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BioLiP

Structure of PDB 4z2d Chain A Binding Site BS02

Receptor Information
>4z2d Chain A (length=485) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMN
ELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLV
DGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANE
REPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEV
TTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKT
GRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFV
IEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAY
IEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDA
EAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADL
ADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4z2d Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
Resolution3.38 Å
Binding residue
(original residue number in PDB)		R119 I172 A173 V174 G175 M176
Binding residue
(residue number reindexed from 1)		R118 I171 A172 V173 G174 M175
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4z2d, PDBe:4z2d, PDBj:4z2d
PDBsum4z2d
PubMed
UniProtQ8DPM2|GYRA_STRR6 DNA gyrase subunit A (Gene Name=gyrA)

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