BioLiP

Structure of PDB 3bsn Chain A Binding Site BS02

Receptor Information

>3bsn Chain A (length=479) Species: 11983 (Norwalk virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KGTYCGAPILGPGSAPKLSTKTKFWRSSTAPLPPGTYEPAYLGGKDPRVK
GGPSLQQVMRDQLKPFTEPRGKPPKPSVLEAAKKTIINVLEQTIDPPDKW
SFAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLADQASKANLMFEEG
KNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGLMD
ELKTHCVTLPIRVGMNMNEDGPIIFERHSRYRYHYDADYSRWDSTQQRAV
LAAALEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFTISINEGLPSGVPC
TSQWNSIAHWLLTLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLD
PEKLTAKLKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFG
KLEQSSILRQMYWTRGPNHEDPSETMIPHSQRPIQLMSLLGEAALHGPAF
YSKISKLVIAELDFYVPRQEPMFRWMRFS

Ligand information

>3bsn Chain T (length=9) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ugcccgggc

.........

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3bsn Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	T117 S118 K127 K166 L184 G186 M192 K207 G218 N220 G301 P303 Y341 N422 Q439
Binding residue (residue number reindexed from 1)	T113 S114 K123 K162 L180 G182 M188 K203 G214 N216 G297 P299 Y337 N418 Q435

Enzymatic activity

Enzyme Commision number

3.4.22.66: calicivirin.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003968	RNA-dependent RNA polymerase activity
GO:0004386	helicase activity
GO:0005524	ATP binding

	Biological Process
GO:0006351	DNA-templated transcription
GO:0039694	viral RNA genome replication

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Molecular Function

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Biological Process

PDB	RCSB:3bsn, PDBe:3bsn, PDBj:3bsn
PDBsum	3bsn
PubMed	18184655
UniProt	Q70ET3