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Structure of PDB 1m6p Chain A Binding Site BS02

Receptor Information >1m6p Chain A (length=146) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] EKTCDLVGEKGKESEKELALLKRLTPLFQKSFESTMYSYVFRVCREAGQH SSGAGLVQIQKSNGKETVVGRFNETQIFQGSNWIMLIYKGGDEYDNHCGR EQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACS

Ligand information Ligand ID M6P InChI InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6+/m1/s1 InChIKey NBSCHQHZLSJFNQ-PQMKYFCFSA-N SMILES Software SMILES CACTVS 3.341 O[CH]1O[CH](CO[P](O)(O)=O)[CH](O)[CH](O)[CH]1O CACTVS 3.341 O[C@H]1O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O OpenEye OEToolkits 1.5.0 C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)OP(=O)(O)O OpenEye OEToolkits 1.5.0 C(C1C(C(C(C(O1)O)O)O)O)OP(=O)(O)O ACDLabs 10.04 O=P(O)(O)OCC1OC(O)C(O)C(O)C1O Formula C6 H13 O9 P Name 6-O-phosphono-alpha-D-mannopyranose; ALPHA-D-MANNOSE-6-PHOSPHATE; 6-O-phosphono-alpha-D-mannose; 6-O-phosphono-D-mannose; 6-O-phosphono-mannose ChEMBL CHEMBL402001 DrugBank DB02900 ZINC ZINC000004096188 PDB chain 1m6p Chain A Residue 200 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1m6p Molecular basis of lysosomal enzyme recognition: three-dimensional structure of the cation-dependent mannose 6-phosphate receptor. Resolution 1.8 Å Binding residue (original residue number in PDB) Y45 Q66 D103 N104 H105 R111 E133 R135 Y143 Binding residue (residue number reindexed from 1) Y37 Q58 D95 N96 H97 R103 E125 R127 Y135 Annotation score 4 Binding affinity MOAD: Kd=8uM PDBbind-CN: -logKd/Ki=5.10,Kd=8uM

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0019904 protein domain specific binding

	Biological Process
GO:0006622	protein targeting to lysosome

	Cellular Component
GO:0005768	endosome
GO:0005794	Golgi apparatus

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