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Structure of PDB 1a36 Chain A Binding Site BS02

Receptor Information >1a36 Chain A (length=544) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKML DHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTE ARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGR GNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLV SWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYRED WKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL HPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL FDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPA KILSYNRANRAVAILCNHQEKSMMNLQTKIDAKKEQLADARRDLKSAKAD AKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKL NFLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF

Ligand information >1a36 Chain C (length=22) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] aaaaatttttctaagtcttttt

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1a36 A model for the mechanism of human topoisomerase I. Resolution 2.8 Å Binding residue (original residue number in PDB) E356 G363 R364 H367 K374 K425 R488 A489 G490 N491 K493 T501 K532 D533 Q578 T585 A586 K587 R708 N745 K746 T747 Binding residue (residue number reindexed from 1) E142 G149 R150 H153 K160 K211 R274 A275 G276 N277 K279 T287 K318 D319 Q364 T371 A372 K373 R487 N524 K525 T526

Enzymatic activity Enzyme Commision number 5.6.2.1: DNA topoisomerase.

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity

	Biological Process
GO:0006265	DNA topological change

	Cellular Component
GO:0005694	chromosome

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