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Structure of PDB 2c37 Chain X Binding Site BS01

Receptor Information >2c37 Chain X (length=241) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] ERPKLILDDGKRTDGRKPDELRSIKIELGVLKNADGSAIFEMGNTKAIAA VYGPKEMHPRHLSLPDRAVLRVRYHMTPFSTDERKNPAPSRREIELSKVI REALESAVLVELFPRTAIDVFTEILQADAGSRLVSLMAASLALADAGIPM RDLIAGVAVGKADGVIILDLNETEDMWGEADMPIAMMPSLNQVTLFQLNG SMTPDEFRQAFDLAVKGINIIYNLEREALKSKYVEFKEEGV

Ligand information Ligand ID U5P InChI InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1 InChIKey DJJCXFVJDGTHFX-XVFCMESISA-N SMILES Software SMILES ACDLabs 10.04 O=C1NC(=O)N(C=C1)C2OC(C(O)C2O)COP(=O)(O)O CACTVS 3.341 O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O OpenEye OEToolkits 1.5.0 C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O OpenEye OEToolkits 1.5.0 C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O CACTVS 3.341 O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O Formula C9 H13 N2 O9 P Name URIDINE-5'-MONOPHOSPHATE ChEMBL CHEMBL214393 DrugBank DB03685 ZINC ZINC000002123545 PDB chain 2c37 Chain X Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2c37 Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core. Resolution 2.8 Å Binding residue (original residue number in PDB) R99 D182 Binding residue (residue number reindexed from 1) R92 D175 Annotation score 4

Enzymatic activity Enzyme Commision number 3.1.13.-

Gene Ontology Molecular Function GO:0000175 3'-5'-RNA exonuclease activity GO:0003723 RNA binding GO:0004527 exonuclease activity GO:0005515 protein binding GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters

	Biological Process
GO:0006401	RNA catabolic process
GO:0016075	rRNA catabolic process

	Cellular Component
GO:0000177	cytoplasmic exosome (RNase complex)
GO:0000178	exosome (RNase complex)
GO:0005737	cytoplasm

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