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Structure of PDB 6icz Chain V Binding Site BS01

Receptor Information >6icz Chain V (length=452) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] KNSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLS RSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRN DKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLK ECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFK DHPIILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKY KAIKKEILTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFPESQTKEL CNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRL ETNKLRNVAKMFAHLLYTDSWSVLECIKLSEETTTSSSRIFVKIFFQELC EYMGLPKLNARLKDETLQPFFEDNPRNTRFAINFFTSIGLGGLTDELREH LK

Ligand information >6icz Chain U (length=26) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] MYNGIGLPTPRGSGTNGYVQRNLSLV

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 6icz Structures of the human spliceosomes before and after release of the ligated exon. Resolution 3.0 Å Binding residue (original residue number in PDB) E470 H474 L477 K478 R513 Binding residue (residue number reindexed from 1) E281 H285 L288 K289 R324

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003723 RNA binding GO:0005515 protein binding

	Biological Process
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0048024	regulation of mRNA splicing, via spliceosome

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005829	cytosol
GO:0016607	nuclear speck
GO:0071005	U2-type precatalytic spliceosome
GO:0071006	U2-type catalytic step 1 spliceosome
GO:0071007	U2-type catalytic step 2 spliceosome
GO:0071013	catalytic step 2 spliceosome

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