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BioLiP

Structure of PDB 2xcr Chain S Binding Site BS01

Receptor Information
>2xcr Chain S (length=718) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVE
KARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAH
IRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKL
KSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEAD
QTFEMLMGDVVENRRQFIEDNAVYANLDFAELPQSRINERNITSEMRESF
LDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYKKSARIVG
DVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMR
FTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGA
SGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAG
LILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQVNKAR
MIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANASVILNNLY
KQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRRTQYNLR
KAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLSEKQA
QAILDMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVLLQLVRDE
LTEIRDRFGDDRRTEIQL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2xcr Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		E435 G436 D437 S438 R1033 K1043 H1046 H1079 H1081 G1082 R1092 S1173 I1175
Binding residue
(residue number reindexed from 1)		E20 G21 D22 S23 R261 K271 H274 H307 H309 G310 R320 S401 I403
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:2xcr, PDBe:2xcr, PDBj:2xcr
PDBsum2xcr
PubMed20686482
UniProtP66937|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB);
Q99XG5|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)

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