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Structure of PDB 8xjl Chain R Binding Site BS01

Receptor Information >8xjl Chain R (length=287) Species: 32630 (synthetic construct) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] NRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVI TDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLL GSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHR DYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGI TLLRVKFSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCE TTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQ

Ligand information Ligand ID UGU InChI InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 InChIKey PXGPLTODNUVGFL-YNNPMVKQSA-N SMILES Software SMILES OpenEye OEToolkits 2.0.7 CCCCCC(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O CACTVS 3.385 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O CACTVS 3.385 CCCCC[CH](O)C=C[CH]1[CH](O)C[CH](O)[CH]1CC=CCCCC(O)=O OpenEye OEToolkits 2.0.7 CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O)O Formula C20 H34 O5 Name (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid; Dinoprost; Prostaglandin F2a; PGF2alpha ChEMBL CHEMBL815 DrugBank DB12789 ZINC ZINC000003830709 PDB chain 8xjl Chain R Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8xjl Structural basis for ligand recognition and activation of the prostanoid receptors Resolution 2.77 Å Binding residue (original residue number in PDB) S33 H81 Y92 M115 T184 T294 Q297 Binding residue (residue number reindexed from 1) S8 H56 Y67 M90 T159 T260 Q263 Annotation score 1

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0004930 G protein-coupled receptor activity GO:0004958 prostaglandin F receptor activity

	Biological Process
GO:0006954	inflammatory response
GO:0007186	G protein-coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007567	parturition
GO:0008284	positive regulation of cell population proliferation
GO:0010628	positive regulation of gene expression
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0043066	negative regulation of apoptotic process
GO:0071799	cellular response to prostaglandin D stimulus

	Cellular Component
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

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