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Structure of PDB 1nmb Chain N Binding Site BS01

Receptor Information >1nmb Chain N (length=388) Species: 11320 (Influenza A virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] REFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRF YALSQGTTIRGKHSNGTIHDRSQYRDLISWPLSSPPTVYNSRVECIGWSS TSCHDGRARMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESEC VCQNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLTGTAKHIEECSC YGEQAGVTCTCRDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPND PTVGKCNDPYPGNNNNGVKGFSYLDGGNTWLGRTISIASRSGYEMLKVPN ALTDDRSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGR PKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL

Ligand information Ligand ID BMA InChI InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1 InChIKey WQZGKKKJIJFFOK-RWOPYEJCSA-N SMILES Software SMILES CACTVS 3.341 OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O OpenEye OEToolkits 1.5.0 C(C1C(C(C(C(O1)O)O)O)O)O CACTVS 3.341 OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O OpenEye OEToolkits 1.5.0 C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O ACDLabs 10.04 OC1C(O)C(OC(O)C1O)CO Formula C6 H12 O6 Name beta-D-mannopyranose; beta-D-mannose; D-mannose; mannose ChEMBL DrugBank ZINC ZINC000003830679 PDB chain 1nmb Chain A Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1nmb The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody Resolution 2.2 Å Binding residue (original residue number in PDB) T391 G394 Binding residue (residue number reindexed from 1) T310 G312 Annotation score 4

Enzymatic activity Catalytic site (original residue number in PDB) R292 Y406 Catalytic site (residue number reindexed from 1) R212 Y324 Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.

Gene Ontology Molecular Function GO:0004308 exo-alpha-sialidase activity GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0046872 metal ion binding

	Biological Process
GO:0005975	carbohydrate metabolic process
GO:0046761	viral budding from plasma membrane

	Cellular Component
GO:0016020	membrane
GO:0020002	host cell plasma membrane
GO:0033644	host cell membrane
GO:0044423	virion component
GO:0055036	virion membrane

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