Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 8wib Chain M Binding Site BS01

Receptor Information >8wib Chain M (length=146) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] PTYTPKAGDTTRSWYVIDASDVVLGRLASAAATLLRGKHKPTFTPNVDGG DFVIVINADKIAVSGDKLTKKFAYRHSGYPGGLRKRTIGELLEKHPTRVV ENAIIGMLPHNKLGRQIQKKLKVYAGPDHPHAAQQPIPFEIKQVAQ

Ligand information >8wib Chain A (length=3022) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaag gacguaggaggcugcgauaagccucggggagcugucaaccgagcguugau ccgaggauguccgaauggggaaacccggcacgagugaugucgugucacca ggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucu caguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcga gcgaaagcggaggauggcuaaaccguaugcaugugauaccggguaggggu ugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggag ggcagugagaaaauguugugguuagcggaaauggcuugggauggccugcc guagacggugagagcccgguacgugaaaacccgacgucugucuugauggu guucccgaguagcagcgggcccguggaaucugcugugaaucugccgggac cacccgguaagccugaauacuucccagugaccgauagcggauuaguaccg ugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaa accgugcgcuuacaauccgucagagcccucgacgugucguggggugaugg cgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguua acccgggugggguagccgcagcgaaagcgagucugaauagggcguaucca cacaagagugugugguguagugguguguucuggacccgaagcggagugau cuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaac ccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggc caaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcag cgucgcauguuucuugccggagguagagcuacuggauggccgaugggccc cacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagag ugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaaca gcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggau gugcagucgcgaagacaacacuggucaagugauugugcgccgauaaugua gcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcugg guaggggagcguccugcauccggugaagccgccgagugaucgaguggugg agggugugggagugagaaugcaggcaugaguagcgauuaggcaagugaga accuugcccgccgaaagaccaaggguuccugggccaggccaguccgccca gggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaac ggguugauauucccguacccguguaugugcguccaugaugaaucagcggu acuaaccaucgcugcaugggaccuucguugguaguagucaagcgaugggg ugacgcaggaagguagccguaccggucagugguaauaccgggguaagccu guagggagucagauagguaaauccgucuggcauauauccugagaggugau gcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagcc ucuagcgaggacauacacggcccguaccccaaaccaacacagguggucag guagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaa aaugcccccguaacuucgggagaagggggacccacauggcguguaagccu uuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguu uacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacug acgccugcccggugcuggaagguuaagaggacccguuaacucccuuuggg ggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaacc auccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaau ggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcac uacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggac cuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggu gggagacugugaagcucacacgccaguguggguggagucguuguugaaau accacucugaucguauugggccucuaaccucggaccguauauccgguuca gggacagugccugguggguaguuuaacuggggcgguugccuccuaaaaug uaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguug aguguaagugcacaagggagcuugacugcgagacggacaugucgagcagg gacgaaagucgggacuagugauccggcaccucugaguggaaggggugucg cucaacggauaaaagguaccccggggauaacaggcugaucuuccccaaga gauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccugg ggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacg cgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgc gcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacgg acgaaccucugguauaccaguugucccaccaggggcacggcuggauagcc acguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuucc aagaccaggcuucucacccucuaggagggauaaggccccccgcagaccac gggauugauagaccagaccuggaagccuaguaauaggugcagggaacugg cacuaaccggccgaaaacuuac <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......< <<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....> >>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<< <<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>. .....>>>>>.>.........<<.....>>..<<<<<<.....<<..... >>....>>>>>>...<<<....<<<<<<<<<<.........(((((.... .>>>>>>>>>>......<<<<<.<.....<<<<<<<))))).>>>>>>>< <<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((. .....<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....>. >.>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..< <<<>>>>>..>>>......>>.>>>>>>>.>>...............<<. ...>>....>>.........<<<<....>>>>.................. >>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>> >...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<.. .<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<< <<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<... ..<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...< <<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>> >......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>< <<<<<<<<....<<<<<<<<.....<<<....<<<.<.<<......<<<< ....>>>>.......>>.>.>>>..>>.>.....>>>>>>>>.......> >>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<..... .>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.. <<<<<<<<<........<......>....>>>>>>>>>.>>......... ..)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>. ...>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>.. .>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<..... ..>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>> >>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<< <<<........>>>>>))<<<<<<<<<<.......<<<<...<<<<<<<. .....<<<<......>>>>.....>>>>>>>.....>>>>.<<...<<<< <...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<< ...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>... >>...<<<......>>>.....>>>>...>>>...>>>>........>>> >>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.< <<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<. ....<<<<<.....<..>......>>>>><<<<<<...<<<<....<<<. ....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<. ........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>. <<<<<.<<<..<<<<<<<..<<<<..<<....<<<<..<<<<<<...>>> >>>...>>>>....>>..>>>>>>>>>..>>>>><<<<<<.......>>> >>>........<...........<<<<<<.....>>>>>>.....>.... >>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((. .<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<< <<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<...............< <<..<<<......<<<<<<<<....>>>>>>>>...>>>........... .>>>......>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>> >>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<....... ....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.... .<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>. <<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>> .............>>>>..>>>>>>.......<<<<...<.<<<<...<< ....>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<< <<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..> ...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>> >....<<<<<<<...<<<<..<<<<<<<...............>>>>>>> .<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>> >.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>> .......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......> >>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>> ..>>>...>>>>....>>>>..

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8wib Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH. Resolution 3.5 Å Binding residue (original residue number in PDB) T3 K7 W15 V24 G26 R27 K39 N47 S65 K68 K71 K72 Y75 H77 S78 Y80 L84 R99 E102 G107 M108 N112 K113 R116 K120 H132 Q135 Q136 K143 Q144 Q147 Binding residue (residue number reindexed from 1) T2 K6 W14 V23 G25 R26 K38 N46 S64 K67 K70 K71 Y74 H76 S77 Y79 L83 R98 E101 G106 M107 N111 K112 R115 K119 H131 Q134 Q135 K142 Q143 Q146

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003729 mRNA binding GO:0003735 structural constituent of ribosome

	Biological Process
GO:0006412	translation
GO:0017148	negative regulation of translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component