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Structure of PDB 8bot Chain H Binding Site BS01

Receptor Information >8bot Chain H (length=642) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] NKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIA LVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQA DFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLK KCDISLQFFLPFSLGGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISL EGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYK SILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFR YGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVF AARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHN YECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAK KDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNM LNPPAEVTTKSQIPLSKIKTLFPLIENPAENFRVLVKQKKASFEEASNQL INHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKV EIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPK

Ligand information >8bot Chain I (length=28) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] gctaataaactaaaaactattattatgg

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8bot Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ. Resolution 7.76 Å Binding residue (original residue number in PDB) I245 K265 Y397 R400 A401 Binding residue (residue number reindexed from 1) I230 K250 Y382 R385 A386

Enzymatic activity Enzyme Commision number 3.6.4.-

Gene Ontology Molecular Function GO:0000976 transcription cis-regulatory region binding GO:0003677 DNA binding GO:0003678 DNA helicase activity GO:0003684 damaged DNA binding GO:0003690 double-stranded DNA binding GO:0003691 double-stranded telomeric DNA binding GO:0003723 RNA binding GO:0004386 helicase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0008047 enzyme activator activity GO:0008094 ATP-dependent activity, acting on DNA GO:0016787 hydrolase activity GO:0016887 ATP hydrolysis activity GO:0031625 ubiquitin protein ligase binding GO:0034511 U3 snoRNA binding GO:0042162 telomeric DNA binding GO:0044877 protein-containing complex binding GO:0045027 DNA end binding GO:0051575 5'-deoxyribose-5-phosphate lyase activity

	Biological Process
GO:0000723	telomere maintenance
GO:0000725	recombinational repair
GO:0002218	activation of innate immune response
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0006974	DNA damage response
GO:0007004	telomere maintenance via telomerase
GO:0009410	response to xenobiotic stimulus
GO:0010558	negative regulation of macromolecule biosynthetic process
GO:0022008	neurogenesis
GO:0032204	regulation of telomere maintenance
GO:0032508	DNA duplex unwinding
GO:0034462	small-subunit processome assembly
GO:0042254	ribosome biogenesis
GO:0045087	innate immune response
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of DNA-templated transcription
GO:0048660	regulation of smooth muscle cell proliferation
GO:0050769	positive regulation of neurogenesis
GO:0060218	hematopoietic stem cell differentiation
GO:0070198	protein localization to chromosome, telomeric region
GO:0071398	cellular response to fatty acid
GO:0071425	hematopoietic stem cell proliferation
GO:0071475	cellular hyperosmotic salinity response
GO:0071480	cellular response to gamma radiation
GO:0071481	cellular response to X-ray
GO:1904430	negative regulation of t-circle formation
GO:1990830	cellular response to leukemia inhibitory factor

	Cellular Component
GO:0000781	chromosome, telomeric region
GO:0000783	nuclear telomere cap complex
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
GO:0016020	membrane
GO:0032040	small-subunit processome
GO:0032991	protein-containing complex
GO:0032993	protein-DNA complex
GO:0034774	secretory granule lumen
GO:0043564	Ku70:Ku80 complex
GO:0070418	DNA-dependent protein kinase complex
GO:0070419	nonhomologous end joining complex
GO:0090734	site of DNA damage
GO:1990904	ribonucleoprotein complex

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