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BioLiP

Structure of PDB 3u8r Chain H Binding Site BS01

Receptor Information
>3u8r Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
E
Ligand information
>3u8r Chain L (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3u8r Rational design and characterization of D-Phe-Pro-D-Arg-derived direct thrombin inhibitors.
Resolution1.47 Å
Binding residue
(original residue number in PDB)		S325 D326 E328 G330 M331 P333 W334 D433 H436 P437 C439 Y454 K455 R457 N484 K532 P534 R538 W539
Binding residue
(residue number reindexed from 1)		S5 D6 E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N156 K204 P206 R210 W211
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3u8r, PDBe:3u8r, PDBj:3u8r
PDBsum3u8r
PubMed22457833
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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