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Structure of PDB 4qz6 Chain G Binding Site BS01

Receptor Information >4qz6 Chain G (length=241) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] GYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVP DKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGY DMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPA GYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHM IDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQ

Ligand information Ligand ID MG InChI InChI=1S/Mg/q+2 InChIKey JLVVSXFLKOJNIY-UHFFFAOYSA-N SMILES Software SMILES ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Mg+2] CACTVS 3.341 [Mg++] Formula Mg Name MAGNESIUM ION ChEMBL DrugBank DB01378 ZINC PDB chain 4qz6 Chain G Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 4qz6 Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Resolution 2.9 Å Binding residue (original residue number in PDB) T8 R122 A123 M125 Binding residue (residue number reindexed from 1) T7 R121 A122 M124 Annotation score 4

Enzymatic activity Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.

Gene Ontology Molecular Function GO:0003674 molecular_function GO:0005515 protein binding

	Biological Process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0010499	proteasomal ubiquitin-independent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051603	proteolysis involved in protein catabolic process

	Cellular Component
GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005839	proteasome core complex
GO:0019773	proteasome core complex, alpha-subunit complex

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