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BioLiP

Structure of PDB 8xhk Chain F Binding Site BS01

Receptor Information
>8xhk Chain F (length=390) Species: 1093098 (Streptomyces albogriseolus 1-36) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLSDGYWDSAARLGVHGAVLQAVPGGRLSAPDGRVAVNMSSYSYLGLDES
PRIIDAAIAALRSNMVLNSSLGRVRMTLPLLEEAECALGDLFGADVATLN
SCSAAAWATLPVLASGLLTDGVAPVMVFDKRAHFCMASLKSLCADETRVE
TIRHNDVDALADICRKNKRVAYVCDSVYSTGGTLAPLEELFALQKEFGLF
LYFDEAHSTSVIGDMGRGYVLDRMGAINDSTMLITSLNKGFGASGGAIVF
GPRDDDRKRKIIQRSSGPLMWSQRLNTPALGAIIESAKLHRSEALPELQA
KLHSNIALFDGLVRAAGQGNSVPIRYLELGSEVDTLEASAYLFDNGFYVE
PDFFPIVSRGAAGLRARIRSSMSTADIEQFAHVWHKLGVD
Ligand information
Ligand IDPLR
InChIInChI=1S/C8H12NO5P/c1-5-7(4-14-15(11,12)13)3-9-6(2)8(5)10/h3,10H,4H2,1-2H3,(H2,11,12,13)
InChIKeyRBCOYOYDYNXAFA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C)c1O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C)C
OpenEye OEToolkits 1.5.0Cc1c(cnc(c1O)C)COP(=O)(O)O
FormulaC8 H12 N O5 P
Name(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE;
4'-DEOXYPYRIDOXINE PHOSPHATE
ChEMBLCHEMBL1235333
DrugBank
ZINCZINC000001656021
PDB chain8xhk Chain D Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8xhk Structural and mechanistic investigations on CC bond forming alpha-oxoamine synthase allowing L-glutamate as substrate.
Resolution2.79 Å
Binding residue
(original residue number in PDB)		R88 S287 Q288
Binding residue
(residue number reindexed from 1)		R73 S272 Q273
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.47: 8-amino-7-oxononanoate synthase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links

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