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Structure of PDB 8wib Chain F Binding Site BS01

Receptor Information >8wib Chain F (length=209) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] RKGILGTKLGMTQVFDENNKVVPVTVVKAGPNVVTRIRTTERDGYSAVQL AYGEISPRKVIKPVAGQFAAAGVNPRRHVAELRLDDEAAVAEYEVGQELT AEIFSDGAYVDVTGTSKGKGFAGTMKRHGFRGQGAAHGAQAVHRRPGSIG TPGRVFKGTRMSGRMGNDRVTTQNLKVHKVDAENGVLLIKGAIPGRNGGL VVVRSAIKR

Ligand information >8wib Chain A (length=3022) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaag gacguaggaggcugcgauaagccucggggagcugucaaccgagcguugau ccgaggauguccgaauggggaaacccggcacgagugaugucgugucacca ggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucu caguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcga gcgaaagcggaggauggcuaaaccguaugcaugugauaccggguaggggu ugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggag ggcagugagaaaauguugugguuagcggaaauggcuugggauggccugcc guagacggugagagcccgguacgugaaaacccgacgucugucuugauggu guucccgaguagcagcgggcccguggaaucugcugugaaucugccgggac cacccgguaagccugaauacuucccagugaccgauagcggauuaguaccg ugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaa accgugcgcuuacaauccgucagagcccucgacgugucguggggugaugg cgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguua acccgggugggguagccgcagcgaaagcgagucugaauagggcguaucca cacaagagugugugguguagugguguguucuggacccgaagcggagugau cuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaac ccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggc caaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcag cgucgcauguuucuugccggagguagagcuacuggauggccgaugggccc cacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagag ugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaaca gcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggau gugcagucgcgaagacaacacuggucaagugauugugcgccgauaaugua gcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcugg guaggggagcguccugcauccggugaagccgccgagugaucgaguggugg agggugugggagugagaaugcaggcaugaguagcgauuaggcaagugaga accuugcccgccgaaagaccaaggguuccugggccaggccaguccgccca gggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaac ggguugauauucccguacccguguaugugcguccaugaugaaucagcggu acuaaccaucgcugcaugggaccuucguugguaguagucaagcgaugggg ugacgcaggaagguagccguaccggucagugguaauaccgggguaagccu guagggagucagauagguaaauccgucuggcauauauccugagaggugau gcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagcc ucuagcgaggacauacacggcccguaccccaaaccaacacagguggucag guagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaa aaugcccccguaacuucgggagaagggggacccacauggcguguaagccu uuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguu uacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacug acgccugcccggugcuggaagguuaagaggacccguuaacucccuuuggg ggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaacc auccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaau ggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcac uacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggac cuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggu gggagacugugaagcucacacgccaguguggguggagucguuguugaaau accacucugaucguauugggccucuaaccucggaccguauauccgguuca gggacagugccugguggguaguuuaacuggggcgguugccuccuaaaaug uaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguug aguguaagugcacaagggagcuugacugcgagacggacaugucgagcagg gacgaaagucgggacuagugauccggcaccucugaguggaaggggugucg cucaacggauaaaagguaccccggggauaacaggcugaucuuccccaaga gauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccugg ggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacg cgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgc gcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacgg acgaaccucugguauaccaguugucccaccaggggcacggcuggauagcc acguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuucc aagaccaggcuucucacccucuaggagggauaaggccccccgcagaccac gggauugauagaccagaccuggaagccuaguaauaggugcagggaacugg cacuaaccggccgaaaacuuac <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......< <<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....> >>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<< <<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>. .....>>>>>.>.........<<.....>>..<<<<<<.....<<..... >>....>>>>>>...<<<....<<<<<<<<<<.........(((((.... .>>>>>>>>>>......<<<<<.<.....<<<<<<<))))).>>>>>>>< <<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((. .....<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....>. >.>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..< <<<>>>>>..>>>......>>.>>>>>>>.>>...............<<. ...>>....>>.........<<<<....>>>>.................. >>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>> >...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<.. .<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<< <<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<... ..<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...< <<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>> >......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>< <<<<<<<<....<<<<<<<<.....<<<....<<<.<.<<......<<<< ....>>>>.......>>.>.>>>..>>.>.....>>>>>>>>.......> >>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<..... .>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.. <<<<<<<<<........<......>....>>>>>>>>>.>>......... ..)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>. ...>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>.. .>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<..... ..>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>> >>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<< <<<........>>>>>))<<<<<<<<<<.......<<<<...<<<<<<<. .....<<<<......>>>>.....>>>>>>>.....>>>>.<<...<<<< <...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<< ...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>... >>...<<<......>>>.....>>>>...>>>...>>>>........>>> >>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.< <<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<. ....<<<<<.....<..>......>>>>><<<<<<...<<<<....<<<. ....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<. ........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>. <<<<<.<<<..<<<<<<<..<<<<..<<....<<<<..<<<<<<...>>> >>>...>>>>....>>..>>>>>>>>>..>>>>><<<<<<.......>>> >>>........<...........<<<<<<.....>>>>>>.....>.... >>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((. .<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<< <<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<...............< <<..<<<......<<<<<<<<....>>>>>>>>...>>>........... .>>>......>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>> >>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<....... ....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.... .<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>. <<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>> .............>>>>..>>>>>>.......<<<<...<.<<<<...<< ....>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<< <<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..> ...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>> >....<<<<<<<...<<<<..<<<<<<<...............>>>>>>> .<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>> >.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>> .......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......> >>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>> ..>>>...>>>>....>>>>..

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8wib Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH. Resolution 3.5 Å Binding residue (original residue number in PDB) M13 R38 R40 Y47 R60 K61 I63 K64 P65 Q69 E83 R85 S118 K119 K121 G122 F123 G125 K128 F132 R133 Q135 G136 A137 A138 H139 G140 Q142 A143 V144 H145 R146 R147 P148 G149 S150 I151 G152 T156 P157 G158 R159 V160 K162 T164 R165 M166 S167 R169 R174 Q178 N179 L180 G196 R201 Binding residue (residue number reindexed from 1) M11 R36 R38 Y45 R58 K59 I61 K62 P63 Q67 E81 R83 S116 K117 K119 G120 F121 G123 K126 F130 R131 Q133 G134 A135 A136 H137 G138 Q140 A141 V142 H143 R144 R145 P146 G147 S148 I149 G150 T151 P152 G153 R154 V155 K157 T159 R160 M161 S162 R164 R169 Q173 N174 L175 G191 R196

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component