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Structure of PDB 8wi8 Chain F Binding Site BS01

Receptor Information >8wi8 Chain F (length=214) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] ARKGILGTKLGMTQVFDENNKVVPVTVVKAGPNVVTRIRTTERDGYSAVQ LAYGEISPRKVIKPVAGQFAAAGVNPRRHVAELRLDDEAAVAEYEVGQEL TAEIFSDGAYVDVTGTSKGKGFAGTMKRHGFRGQGAAHGAQAVHRRPGSI GGCATPGRVFKGTRMSGRMGNDRVTTQNLKVHKVDAENGVLLIKGAIPGR NGGLVVVRSAIKRG

Ligand information >8wi8 Chain A (length=3025) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaag gacguaggaggcugcgauaagccucggggagcugucaaccgagcguugau ccgaggauguccgaauggggaaacccggcacgagugaugucgugucacca ggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucu caguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcga gcgaaagcggaggauggcuaaaccguaugcaugugauaccggguaggggu ugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggag ggcagugagaaaauguugugguuagcggaaauggcuugggauggccugcc guagacggugagagcccgguacgugaaaacccgacgucugucuugauggu guucccgaguagcagcgggcccguggaaucugcugugaaucugccgggac cacccgguaagccugaauacuucccagugaccgauagcggauuaguaccg ugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaa accgugcgcuuacaauccgucagagcccucgacgugucguggggugaugg cgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguua acccgggugggguagccgcagcgaaagcgagucugaauagggcguaucca cacaagagugugugguguagugguguguucuggacccgaagcggagugau cuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaac ccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggc caaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcag cgucgcauguuucuugccggagguagagcuacuggauggccgaugggccc cacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagag ugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaaca gcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggau gugcagucgcgaagacaacacuggucaagugauugugcgccgauaaugua gcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcugg guaggggagcguccugcauccggugaagccgccgagugaucgaguggugg agggugugggagugagaaugcaggcaugaguagcgauuaggcaagugaga accuugcccgccgaaagaccaaggguuccugggccaggccaguccgccca gggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaac ggguugauauucccguacccguguaugugcguccaugaugaaucagcggu acuaaccauccaugcaugggaccuucguugguaguagucaagcgaugggg ugacgcaggaagguagccguaccggucagugguaauaccgggguaagccu guagggagucagauagguaaauccgucuggcauauauccugagaggugau gcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagcc ucuagcgaggacauacacggcccguaccccaaaccaacacagguggucag guagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaa aaugcccccguaacuucgggagaagggggacccacauggcguguaagccu uuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguu uacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacug acgccugcccggugcuggaagguuaagaggacccguuaacucccuuuggg ggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaacc auccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaau ggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcac uacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggac cuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggu gggagacugugaagcucacacgccaguguggguggagucguuguugaaau accacucugaucguauugggccucuaaccucggaccguauauccgguuca gggacagugccugguggguaguuuaacuggggcgguugccuccuaaaaug uaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguug aguguaagugcacaagggagcuugacugcgagacggacaugucgagcagg gacgaaagucgggacuagugauccggcaccucugaguggaaggggugucg cucaacggauaaaagguaccccggggauaacaggcugaucuuccccaaga guccauaucgacgggaugguuuggcaccucgaugucggcucgucgcaucc uggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggc acgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccg cgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccggga cggacgaaccucugguauaccaguugucccaccaggggcacggcuggaua gccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucu uccaagaccaggcuucucacccucuaggagggauaaggccccccgcagac cacgggauugauagaccagaccuggaagccuaguaauaggugcagggaac uggcacuaaccggccgaaaacuuac <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......< <<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....> >>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<< <<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>. .....>>>>>.>.........<<.....>>..<<<<<<.....<<..... >>....>>>>>>...<<<....<<<<<<<<<<.........(((((.... .>>>>>>>>>>......<<<<..<.....<<<<<<<))))).>>>>>>>< <<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((. .....<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....>. ..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..< <<<>>>>>..>>>......>>.>>>>>>>.>>...............<<. ...>>....>>.........<<<<....>>>>.................. >>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>> >...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<.. .<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<< <<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<... ..<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...< <<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>> >......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>< <<<<<<<<....<<<<<<<<.....<<<....<<<.<.<<......<<<< ....>>>>.......>>.>.>>>..>>.>.....>>>>>>>>.......> >>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<..... .>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.. <<<<<<<<<........<......>....>>>>>>>>>.>>......... ..)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>. ...>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>.. .>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<..... ..>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>> >>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<< <<<........>>>>>))<<<<<<<<<<.......<<<<..<<<<<<<<. .....<<<<......>>>>.....>>>>>>>>....>>>>.<<...<<<< <...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<< ...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>... >>...<<<......>>>.....>>>>...>>>...>>>>........>>> >>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.< <<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<. ....<<<<<....<<..>>.....>>>>><<<<<<...<<<<....<<<. ....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<. ........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>. <<<<<.<<<..<<<<<<<..<<<..<<<....<<<<<.<<<<<<...>>> >>>..>>>>>....>>>..>>>>>>>>..>>>>><<<<<<.......>>> >>>........<...........<<<<<<.....>>>>>>.....>.... >>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((. .<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<< <<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<<..............< <<..<<<......<<<<<<<<....>>>>>>>>...>>>........... .>>>.....>>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>> >>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<....... ....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.... .<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>. <<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>> .............>>>>..>>>>>>.......<<<<...<.<<<<...<< .......>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<< <<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>> ..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>> >>>>....<<<<<<<...<<<<..<<<<<<<...............>>>> >>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>... >>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.> >>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<..... ..>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..> >>>..>>>...>>>>....>>>>..

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8wi8 Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH. Resolution 2.7 Å Binding residue (original residue number in PDB) M13 T14 Q15 P25 R38 R40 R44 D45 Y47 R60 K61 I63 K64 P65 G68 Q69 R79 V81 E83 R85 S118 K119 G120 K121 G122 F123 G125 F132 R133 Q135 A137 A138 H139 G140 Q142 A143 V144 H145 R146 R147 P148 G149 S150 I151 G152 G153 C154 A155 T156 P157 G158 R159 V160 K162 G163 T164 R165 M166 S167 R169 N172 R174 Q178 N179 I198 P199 R201 K213 Binding residue (residue number reindexed from 1) M12 T13 Q14 P24 R37 R39 R43 D44 Y46 R59 K60 I62 K63 P64 G67 Q68 R78 V80 E82 R84 S117 K118 G119 K120 G121 F122 G124 F131 R132 Q134 A136 A137 H138 G139 Q141 A142 V143 H144 R145 R146 P147 G148 S149 I150 G151 G152 C153 A154 T155 P156 G157 R158 V159 K161 G162 T163 R164 M165 S166 R168 N171 R173 Q177 N178 I197 P198 R200 K212

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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