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Structure of PDB 1fft Chain F Binding Site BS01

Receptor Information >1fft Chain F (length=501) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] VDHKRLGIMYIIVAIVMLLRGFADAIMMRSQQALASAGEAGFLPPHHYDQ IFTAHGVIMIFFVAMPFVIGLMNLVVPLQIGARDVAFPFLNNLSFWFTVV GVILVNVSLGVGEFAQTGWLAYPPLSGIEYSPGVGVDYWIWSLQLSGIGT TLTGINFFVTILKMRAPGMTMFKMPVFTWASLCANVLIIASFPILTVTVA LLTLDRYLGTHFFTNDMGGNMMMYINLIWAWGHPEVYILILPVFGVFSEI AATFSRKRLFGYTSLVWATVCITVLSFIVWLHHFFTMGAGANVNAFFGIT TMIIAIPTGVKIFNWLFTMYQGRIVFHSAMLWTIGFIVTFSVGGMTGVLL AVPGADFVLHNSLFLIAHFHNVIIGGVVFGCFAGMTYWWPKAFGFKLNET WGKRAFWFWIIGFFVAFMPLYALGFMGMTRRLSQQIDPQFHTMLMIAASG AVLIALGILCLVIQMYVSIRDRDQNRDLTGDPWGGRTLEWATSSPPPFYN F

Ligand information Ligand ID CU InChI InChI=1S/Cu/q+2 InChIKey JPVYNHNXODAKFH-UHFFFAOYSA-N SMILES Software SMILES ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Cu+2] CACTVS 3.341 [Cu++] Formula Cu Name COPPER (II) ION ChEMBL DrugBank DB14552 ZINC PDB chain 1fft Chain F Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1fft The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site. Resolution 3.5 Å Binding residue (original residue number in PDB) H284 H333 H334 Binding residue (residue number reindexed from 1) H233 H282 H283 Annotation score 1

Enzymatic activity Catalytic site (original residue number in PDB) Y61 R71 D75 M79 F103 H106 N124 D135 N142 S145 T149 W170 G200 T201 T204 T211 H284 E286 Y288 S299 S315 T359 K362 H419 F420 H421 Catalytic site (residue number reindexed from 1) Y10 R20 D24 M28 F52 H55 N73 D84 N91 S94 T98 W119 G149 T150 T153 T160 H233 E235 Y237 S248 S264 T308 K311 H368 F369 H370 Enzyme Commision number 7.1.1.3: ubiquinol oxidase (H(+)-transporting).

Gene Ontology Molecular Function GO:0004129 cytochrome-c oxidase activity GO:0005507 copper ion binding GO:0005515 protein binding GO:0009055 electron transfer activity GO:0009486 cytochrome bo3 ubiquinol oxidase activity GO:0015078 proton transmembrane transporter activity GO:0015453 oxidoreduction-driven active transmembrane transporter activity GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor GO:0020037 heme binding GO:0046872 metal ion binding GO:0048039 ubiquinone binding

	Biological Process
GO:0009060	aerobic respiration
GO:0015990	electron transport coupled proton transport
GO:0019646	aerobic electron transport chain
GO:0022904	respiratory electron transport chain
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0009319	cytochrome o ubiquinol oxidase complex
GO:0016020	membrane

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