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BioLiP

Structure of PDB 7q5t Chain DDD Binding Site BS01

Receptor Information
>7q5t Chain DDD (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR
KAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNR
PQGVQPKTGPFEDLKENLIREYVKQTWNALEQAIISQKPQLEKLIATTAH
EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKV
LHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIG
Ligand information
>7q5t Chain III (length=19) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GVYTGLSTRNQETYETLKH
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7q5t The tandem SH2 domains of SYK
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R22 R42 R45 H63 Y64 T65 D97 G98 R175 R195 R197 H215 Y216 R217 I228 P229 E230 G231 K232 K247 D249 G250
Binding residue
(residue number reindexed from 1)		R13 R33 R36 H54 Y55 T56 D88 G89 R162 R182 R184 H202 Y203 R204 I215 P216 E217 G218 K219 K234 D236 G237
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:7q5t, PDBe:7q5t, PDBj:7q5t
PDBsum7q5t
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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