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Structure of PDB 7n06 Chain D Binding Site BS01

Receptor Information

>7n06 Chain D (length=347) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EMSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTT
LPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHIST
IGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSV
KGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSR
NLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGL
HLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLL
LDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKL

Ligand information

>7n06 Chain J (length=3) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

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Receptor-Ligand Complex Structure

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Structure summary

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PDB	7n06 Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	H235 G248 H250 K290 W333 T341 Y343
Binding residue (residue number reindexed from 1)	H236 G249 H251 K291 W334 T342 Y344

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-

External links

PDB	RCSB:7n06, PDBe:7n06, PDBj:7n06
PDBsum	7n06
PubMed	34403466
UniProt	P0DTD1\|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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