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Structure of PDB 4zro Chain D Binding Site BS01

Receptor Information
>4zro Chain D (length=299) Species: 33734 (Feline infectious peritonitis virus (strain 79-1146)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGLRKMAQPSGVVEPCIVRVAYGNNVLNGLWLGDEVICPRHVIASDTSRV
INYENELSSVRLHNFSIAKNNAFLGVVSAKYKGVNLVLKVNQVNPNTPEH
KFKSVRPGESFNILACYEGCPGSVYGVNMRSQGTIKGSFIAGTCGSVGYV
LENGTLYFVYMHHLELGNGSHVGSNLEGEMYGGYEDQPSMQLEGTNVMSS
DNVVAFLYAALINGERWFVTNTSMTLESYNAWAKTNSFTEIVSTDAFNML
AAKTGYSVEKLLECIVRLNKGFGGRTILSYGSLCDEFTPTEVIRQMYGV
Ligand information
Receptor-Ligand Complex Structure
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PDB4zro X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design.
Resolution2.0566 Å
Binding residue
(original residue number in PDB)		F139 G142 C144 H162 H163 L164 E165 P188 S189 Q191
Binding residue
(residue number reindexed from 1)		F139 G142 C144 H162 H163 L164 E165 P188 S189 Q191
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 C144
Catalytic site (residue number reindexed from 1) H41 G142 C144
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:4zro, PDBe:4zro, PDBj:4zro
PDBsum4zro
PubMed26592814
UniProtQ98VG9|R1AB_FIPV Replicase polyprotein 1ab (Gene Name=rep)

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