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BioLiP

Structure of PDB 8xhk Chain C Binding Site BS01

Receptor Information
>8xhk Chain C (length=393) Species: 1093098 (Streptomyces albogriseolus 1-36) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLRHLSDGYWDSAARLGVHGAVLQAVPGGRLSAPDGRVAVNMSSYSYLGL
DESPRIIDAAIAALRSNMVLNSSLGRVRMTLPLLEEAECALGDLFGADVA
TLNSCSAAAWATLPVLASGLLTDGVAPVMVFDKRAHFCMASLKSLCADET
RVETIRHNDVDALADICRKNKRVAYVCDSVYSTGGTLAPLEELFALQKEF
GLFLYFDEAHSTSVIGDMGRGYVLDRMGAINDSTMLITSLNKGFGASGGA
IVFGPRDDDRKRKIIQRSSGPLMWSQRLNTPALGAIIESAKLHRSEALPE
LQAKLHSNIALFDGLVRAAGQGNSVPIRYLELGSEVDTLEASAYLFDNGF
YVEPDFFPIVSRGAAGLRARIRSSMSTADIEQFAHVWHKLGVD
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain8xhk Chain C Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8xhk Structural and mechanistic investigations on CC bond forming alpha-oxoamine synthase allowing L-glutamate as substrate.
Resolution2.79 Å
Binding residue
(original residue number in PDB)		C117 S118 H148 D219 A221 H222 S251 K254
Binding residue
(residue number reindexed from 1)		C105 S106 H136 D207 A209 H210 S239 K242
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.47: 8-amino-7-oxononanoate synthase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links

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