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Structure of PDB 8qqu Chain C Binding Site BS01

Receptor Information >8qqu Chain C (length=519) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] REITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVL GNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDG QGNFGSIDGDSAAAMRFTEIRLAKIAHELMADLEKETVDFVDNYDGTEKI PDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISI EGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTG RETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVI EVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFV RHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAE AKTALVANPWQLGNVAAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQA QAILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREE LELVREQFGDKRRTEITAN

Ligand information >8qqu Chain E (length=16) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] tttttttttttttttt

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8qqu Structural basis of DNA crossover capture by E. coli DNA gyrase Resolution 2.9 Å Binding residue (original residue number in PDB) Y21 I174 V176 K239 K276 S329 Binding residue (residue number reindexed from 1) Y16 I169 V171 K234 K271 S324

Enzymatic activity Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0003916 DNA topoisomerase activity GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity GO:0005515 protein binding GO:0005524 ATP binding GO:0008094 ATP-dependent activity, acting on DNA GO:0034335 DNA negative supercoiling activity GO:0042802 identical protein binding

	Biological Process
GO:0006259	DNA metabolic process
GO:0006261	DNA-templated DNA replication
GO:0006265	DNA topological change
GO:0006351	DNA-templated transcription
GO:0009410	response to xenobiotic stimulus
GO:0046677	response to antibiotic
GO:0051276	chromosome organization
GO:2000104	negative regulation of DNA-templated DNA replication

	Cellular Component
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0009330	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0016020	membrane

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