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Structure of PDB 8g0h Chain C Binding Site BS01

Receptor Information
>8g0h Chain C (length=227) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWY
HFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEASKKEKDKDSKL
EKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVA
DGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWV
TPKEFREISYLKKLKVKKQDRIFPPET
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g0h Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks
Resolution3.8 Å
Binding residue
(original residue number in PDB)		K15 S16 A19 S20 R34 F44 V48 S274 G275
Binding residue
(residue number reindexed from 1)		K13 S14 A17 S18 R32 F42 V46 S140 G141
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:8g0h, PDBe:8g0h, PDBj:8g0h
PDBsum8g0h
PubMed38372302
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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