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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 6eop Chain C Binding Site BS01

Receptor Information >6eop Chain C (length=837) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] LEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSD RIYYLAMRENTLFYSEIPKTINRAAVLMLSWKPLLDLYSREEELLRERKR IGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETS CPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANME EDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESE VEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPE LFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSH EEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKE EIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNP GEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPT CKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGK KYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHR GLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYL SLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGS VAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIY PQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKV

Ligand information >6eop Chain F (length=8) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] SLRFLYEG

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 6eop Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Resolution 2.4 Å Binding residue (original residue number in PDB) R160 E275 E276 Y669 V674 W754 S755 Y756 V781 W784 Y787 Y791 H865 S866 I867 G873 E877 Binding residue (residue number reindexed from 1) R100 E215 E216 Y609 V614 W694 S695 Y696 V721 W724 Y727 Y731 H805 S806 I807 G813 E817

Enzymatic activity Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865 Catalytic site (residue number reindexed from 1) Y609 S695 Y696 D773 H805 Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.

Gene Ontology Molecular Function GO:0004177 aminopeptidase activity GO:0005515 protein binding GO:0008236 serine-type peptidase activity GO:0008239 dipeptidyl-peptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006955	immune response
GO:0043069	negative regulation of programmed cell death

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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