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Structure of PDB 5wmh Chain C Binding Site BS01

Receptor Information >5wmh Chain C (length=401) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] DMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVA EAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGA KQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNF LLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLL VLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYL AGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAY RERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSS SLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEP L

Ligand information Ligand ID PLP InChI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) InChIKey NGVDGCNFYWLIFO-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O OpenEye OEToolkits 1.5.0 Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O ACDLabs 10.04 O=P(O)(O)OCc1cnc(c(O)c1C=O)C Formula C8 H10 N O6 P Name PYRIDOXAL-5'-PHOSPHATE; VITAMIN B6 Phosphate ChEMBL CHEMBL82202 DrugBank DB00114 ZINC ZINC000001532514 PDB chain 5wmh Chain C Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5wmh Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis. Resolution 3.0 Å Binding residue (original residue number in PDB) G167 A168 W193 D272 I274 Y275 S305 K306 R314 Binding residue (residue number reindexed from 1) G99 A100 W125 D204 I206 Y207 S237 K238 R246 Annotation score 1

Enzymatic activity Enzyme Commision number 2.6.1.1: aspartate transaminase. 2.6.1.78: aspartate--prephenate aminotransferase. 2.6.1.79: glutamate--prephenate aminotransferase.

Gene Ontology Molecular Function GO:0003824 catalytic activity GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity GO:0008483 transaminase activity GO:0030170 pyridoxal phosphate binding GO:0033853 aspartate-prephenate aminotransferase activity GO:0033854 glutamate-prephenate aminotransferase activity

	Biological Process
GO:0006520	amino acid metabolic process
GO:0008652	amino acid biosynthetic process
GO:0009058	biosynthetic process
GO:0009094	L-phenylalanine biosynthetic process
GO:0009095	aromatic amino acid family biosynthetic process, prephenate pathway
GO:0009793	embryo development ending in seed dormancy

	Cellular Component
GO:0005829	cytosol
GO:0009507	chloroplast
GO:0009570	chloroplast stroma

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