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Structure of PDB 5vlc Chain C Binding Site BS01

Receptor Information >5vlc Chain C (length=434) Species: 3880 (Medicago truncatula) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] PIKTYHLSNLTQTELLSLKSRPRIDFSSVFDIVNPIVDDVHAHGDAAVKQ YTSKFDKVDLENIVELVSDLPDPVLDPAIKEAFDVAYSNIYAFHAAQKSP EKSVENMKGVQCKRVARSINSVGLYVPGGTAVLPSTALMLAVPAQIAGCK TIVLANPPTRDGTTCKEVLYCAKKAGVTHLLKAGGAQAISAMAWGTETCP KVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIADKHAIPSH VAADLLSQAEHGPDSQVVLVIAGDGVDQNAIQEEVSKQCQSLPRGEFAAK ALSHSFIVHARDMLEAITFSNMYAPEHLIINVKDAEKWESFIENAGSVFL GSWTPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKYITVQSLTEEGL RKLGPYVETMAEVEGLEAHKRAVTLRLQDIEARQ

Ligand information Ligand ID ZN InChI InChI=1S/Zn/q+2 InChIKey PTFCDOFLOPIGGS-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 [Zn++] ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Zn+2] Formula Zn Name ZINC ION ChEMBL CHEMBL1236970 DrugBank DB14532 ZINC PDB chain 5vlc Chain C Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5vlc Structures of Medicago truncatula L-Histidinol Dehydrogenase Show Rearrangements Required for NAD(+) Binding and the Cofactor Positioned to Accept a Hydride. Resolution 1.97 Å Binding residue (original residue number in PDB) Q299 H302 D401 Binding residue (residue number reindexed from 1) Q258 H261 D360 Annotation score 1

Enzymatic activity Catalytic site (original residue number in PDB) Q299 H302 E367 H368 D401 H460 Catalytic site (residue number reindexed from 1) Q258 H261 E326 H327 D360 H419 Enzyme Commision number 1.1.1.23: histidinol dehydrogenase.

Gene Ontology Molecular Function GO:0000166 nucleotide binding GO:0004399 histidinol dehydrogenase activity GO:0016491 oxidoreductase activity GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0046872 metal ion binding GO:0051287 NAD binding

	Biological Process
GO:0000105	L-histidine biosynthetic process

	Cellular Component
GO:0005737	cytoplasm
GO:0009507	chloroplast

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