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Structure of PDB 2nv9 Chain C Binding Site BS01

Receptor Information >2nv9 Chain C (length=367) Species: 10506 (Paramecium bursaria Chlorella virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MNSVVNNILKAHPHQTKSFYVSSPKIVEDLIDQWTILFPRVTPHYAVKCN NDEVLLKTMCDKNVNFDCASSSEIKKVIQIGVSPSRIIFAHTMKTIDDLI FAKDQGVDIATFDSSFELDKIHTYHPNCKMILRIRCDDPNAAVQLGNKFG ANEDEIRHLLEYAKQLDIEVIGISFHVGSGSRNPEAYYRAIKSSKEAFNE AISVGHKPYILDIGGGLHADILSTMSDYINDAIKDFFPEDTVTIVAEPGR FFAEHYSVLATQVIGKRVRDGLYEYFFNESTYGGFSNVIFEKSVPTPQLL RDVPDDEEYVPSVLYGCTCDGVDVINHNVALPELHIGDWVYFPSWGAYTN VLTTSFNGFGEYDVYYI

Ligand information Ligand ID PLP InChI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) InChIKey NGVDGCNFYWLIFO-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O OpenEye OEToolkits 1.5.0 Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O ACDLabs 10.04 O=P(O)(O)OCc1cnc(c(O)c1C=O)C Formula C8 H10 N O6 P Name PYRIDOXAL-5'-PHOSPHATE; VITAMIN B6 Phosphate ChEMBL CHEMBL82202 DrugBank DB00114 ZINC ZINC000001532514 PDB chain 2nv9 Chain C Residue 2003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2nv9 X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity. Resolution 1.95 Å Binding residue (original residue number in PDB) K48 H176 S179 G215 G216 E252 G254 R255 Y353 Binding residue (residue number reindexed from 1) K48 H176 S179 G215 G216 E247 G249 R250 Y348 Annotation score 1

Enzymatic activity Catalytic site (original residue number in PDB) K48 H176 E252 Catalytic site (residue number reindexed from 1) K48 H176 E247 Enzyme Commision number 4.1.1.19: arginine decarboxylase.

Gene Ontology Molecular Function GO:0003824 catalytic activity GO:0004586 ornithine decarboxylase activity

	Biological Process
GO:0006596	polyamine biosynthetic process
GO:0033387	putrescine biosynthetic process from ornithine

	Cellular Component
GO:0005737	cytoplasm

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