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Structure of PDB 1x27 Chain C Binding Site BS01

Receptor Information

>1x27 Chain C (length=164) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIP
FNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGS
FSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNA
SDGLCTRLSRPCQT

Ligand information

>1x27 Chain K (length=5) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YDYVH

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1x27 Molecular basis for regulation of Src by the docking protein p130Cas
Resolution	2.7 Å
Binding residue (original residue number in PDB)	R134 R154 S156 S164 K179 H180 Y181 K182 S194 G215
Binding residue (residue number reindexed from 1)	R72 R92 S94 S102 K117 H118 Y119 K120 S132 G153

Enzymatic activity

Enzyme Commision number

2.7.10.2: non-specific protein-tyrosine kinase.

External links

PDB	RCSB:1x27, PDBe:1x27, PDBj:1x27
PDBsum	1x27
PubMed	16245368
UniProt	P06239\|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

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