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BioLiP

Structure of PDB 9bha Chain B Binding Site BS01

Receptor Information
>9bha Chain B (length=793) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAP
TSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGI
KVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVD
ELHMLGDSHRGYLLELLLTKICYITRKSASSNAVQIVGMSATLPNLELVA
SWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDH
VVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQACPPVILE
QKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFR
QGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGR
KGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIR
AILEIIVGGVASTSQDMHTYAACTFLAASMKEGVQLGAIEACVMWLLENE
FIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFV
LENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGF
LARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGC
NRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQREL
CDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSAR
KAVDEEEEAVEERRNMRTIWLTEREAAALIVEEARMILQQDLV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB9bha Human polymerase theta helicase positions DNA microhomologies for double-strand break repair
Resolution3.5 Å
Binding residue
(original residue number in PDB)		F146 V147 G173 S174 E192 R193 R200 S346 K347 K348 K352 A418 T443 S444 T445 G466 R467 K497 S622 V757 Y758 G760 M761
Binding residue
(residue number reindexed from 1)		F80 V81 G107 S108 E126 R127 R134 S271 K272 K273 K277 A335 T360 S361 T362 G383 R384 K414 S529 V664 Y665 G667 M668
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:9bha, PDBe:9bha, PDBj:9bha
PDBsum9bha
PubMed
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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