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Structure of PDB 8w6p Chain B Binding Site BS01

Receptor Information >8w6p Chain B (length=413) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] AVGQFWHVTDLHLDPTYHITDDRTKVCASSKGANASNPGPFGDVLCDSPY QLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMT VQNLFPNLQVFPALGNHDYWPQDQLPIVTSKVYSAVADLWKPWLGEEAIS TLKKGGFYSQKVASNPGLRIISLNTNLYYGPNIMTLNKTDPANQFEWLEN TLNSSLWNKEKVYIIAHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSV IAGQFYGHTHRDSLMVLSDKNGNPLNSVFVAPAVTPVKGVLQKETNNPGV RLFQYKPGDYTLLDMVQYYLNLTEANLKGESNWTLEYVLTQAYSVADLQP KSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQHCKTLQVCAIMNL DSMSYDDCLKQHL

Ligand information Ligand ID PO4 InChI InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3 InChIKey NBIIXXVUZAFLBC-UHFFFAOYSA-K SMILES Software SMILES CACTVS 3.341 [O-][P]([O-])([O-])=O ACDLabs 10.04 [O-]P([O-])([O-])=O OpenEye OEToolkits 1.5.0 [O-]P(=O)([O-])[O-] Formula O4 P Name PHOSPHATE ION ChEMBL DrugBank DB14523 ZINC PDB chain 8w6p Chain B Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8w6p SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Resolution 1.91 Å Binding residue (original residue number in PDB) D107 H111 N148 H149 H290 H292 Binding residue (residue number reindexed from 1) D75 H79 N116 H117 H258 H260 Annotation score 1

Enzymatic activity Enzyme Commision number 3.1.4.- 3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology Molecular Function GO:0004767 sphingomyelin phosphodiesterase activity GO:0008081 phosphoric diester hydrolase activity GO:0008270 zinc ion binding GO:0016787 hydrolase activity GO:0016887 ATP hydrolysis activity GO:0046872 metal ion binding

	Biological Process
GO:0006685	sphingomyelin catabolic process
GO:0008150	biological_process
GO:0009143	nucleoside triphosphate catabolic process
GO:0160049	negative regulation of cGAS/STING signaling pathway

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space

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