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BioLiP

Structure of PDB 8gcc Chain B Binding Site BS01

Receptor Information
>8gcc Chain B (length=707) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGIPKLDDANEAGGKYSHRCTLILTEGDSAKALCTAGLAVKDRDYFGVFP
LRGKPLNVRDATLKKVMACAEFQAVSKIMGLDIRQKYSGVERLRYGHLMI
MSDQDHDGSHIKGLIINMIHHYWPDLIKTPGFLQQFITPIVKARISFFSM
PDYFEWKNAIGDGIRNYEIRYYKGLGTSGAKEGREYFENIDRHRLDFVHE
DATDDARIVMAFAKDKVEERKHWITQFKANTNVNESMNYNVRTVRYSEFV
DKELILFSVADCERSIPSVIDGLKPGQRKIIFSSFKRRLTRSIKVVQLAG
YVSEHAAYHHGEQSLVQTIVGLAQNFVGSNNVPLLQQDGQFGTRLQGGKD
HAAGRYIFTRLTNIARYIYHPSDDFVVDYKDDDGLSVEPFYYVPVIPMVL
VNGTSGIGTGFATNIPNYSPLEVIDNLMRLLRGEEVQPMKPWYFGFAGTI
EEKEKGKFVSTGCANVRPDGVVQITELPIGTWTQGYKKFLEELREKEVVV
QYREHNTDVTVDFEVFLHPEVLHHWVAQGCVEERLQLREYIHATNIIAFD
REGQITKYRDAEAVLKEFYLVRLEYYAKRRDFLIGDLRSVASKLENMVRF
VTEVVDGRLIVTRRRKKELLEELRQRGYAPFPEMRRAARDYDYLLGMRLW
NLTAEMIARLQSQLQKARDELAALEKRTPKDLWAEDLNQLRPRIENLFEE
RAKEIAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8gcc Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Resolution2.94 Å
Binding residue
(original residue number in PDB)		D436 R460 Y727 H729 G730 S733 S824 I826
Binding residue
(residue number reindexed from 1)		D28 R52 Y308 H310 G311 S314 S405 I407
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links

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