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BioLiP

Structure of PDB 6iid Chain B Binding Site BS01

Receptor Information
>6iid Chain B (length=290) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKAVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDA
DRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMAET
FYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGD
GKKIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIG
FQPQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEF
TLYLSTRKIEGLEKIMENLKNAEIEPDDYFMSRYEKKLEE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6iid A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.
Resolution2.986 Å
Binding residue
(original residue number in PDB)		R109 S137 R138 G139 P143 G145 F168 N171 S172 N176 R183 L311 R314
Binding residue
(residue number reindexed from 1)		R52 S80 R81 G82 P86 G88 F111 N114 S115 N119 R126 L254 R257
Binding affinityPDBbind-CN: Kd=1.03uM
Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C55 A83 N105 N114 E122
Enzyme Commision number 3.1.30.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6iid, PDBe:6iid, PDBj:6iid
PDBsum6iid
PubMed30949702
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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