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Structure of PDB 5luz Chain B Binding Site BS01

Receptor Information >5luz Chain B (length=665) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] GSSSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTY ENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIE MSMRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQ NEIKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTD DDKYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLP LRTKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAERE FILNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFP IEVVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQF YLDLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQGRPSLLR HDEVRTYFHQFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWD VDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSL HTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLW SEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKR EPNQKAFLMSRGLHA

Ligand information >5luz Chain D (length=5) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] KPRRP

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5luz Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin. Resolution 2.7 Å Binding residue (original residue number in PDB) D84 H88 D103 N180 A426 C428 F429 Y606 Y613 Binding residue (residue number reindexed from 1) D72 H76 D91 N168 A414 C416 F417 Y591 Y598

Enzymatic activity Enzyme Commision number 3.4.24.16: neurolysin.

Gene Ontology Molecular Function GO:0004222 metalloendopeptidase activity GO:0008233 peptidase activity GO:0008237 metallopeptidase activity GO:0042277 peptide binding GO:0046872 metal ion binding

	Biological Process
GO:0006111	regulation of gluconeogenesis
GO:0006508	proteolysis
GO:0006518	peptide metabolic process
GO:0007186	G protein-coupled receptor signaling pathway
GO:1902809	regulation of skeletal muscle fiber differentiation

	Cellular Component
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0005886	plasma membrane

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