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Structure of PDB 4r07 Chain B Binding Site BS01

Receptor Information >4r07 Chain B (length=738) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] RSYPCDEKVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGL QNLTKINLNHNPNVNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPES LTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVF ETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLIN LTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSST SLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFN YIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLS TINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPDFEFDPHSNFYHFTR PLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLS GTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAG VTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDI LWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHIN DNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHN RISHLPSGFLSEVSSLKHLDLSSNLLKTINKTKLSMLELHGNPFECTCDI GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLE

Ligand information Ligand ID URI InChI InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 InChIKey DRTQHJPVMGBUCF-XVFCMESISA-N SMILES Software SMILES CACTVS 3.341 OC[CH]1O[CH]([CH](O)[CH]1O)N2C=CC(=O)NC2=O OpenEye OEToolkits 1.5.0 C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O ACDLabs 10.04 O=C1NC(=O)N(C=C1)C2OC(C(O)C2O)CO OpenEye OEToolkits 1.5.0 C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O CACTVS 3.341 OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O Formula C9 H12 N2 O6 Name URIDINE ChEMBL CHEMBL100259 DrugBank DB02745 ZINC ZINC000002583633 PDB chain 4r07 Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 4r07 Toll-like receptor 8 senses degradation products of single-stranded RNA Resolution 2.0 Å Binding residue (original residue number in PDB) D543 D545 V573 T574 Binding residue (residue number reindexed from 1) D471 D473 V501 T502 Annotation score 4 Binding affinity MOAD: Kd=55uM

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0004888 transmembrane signaling receptor activity

	Biological Process
GO:0002224	toll-like receptor signaling pathway
GO:0006955	immune response

	Cellular Component
GO:0016020	membrane

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