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BioLiP

Structure of PDB 4ch2 Chain B Binding Site BS01

Receptor Information
>4ch2 Chain B (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ch2 Gpibalpha Interacts Exclusively with Exosite II of Thrombin
Resolution1.6 Å
Binding residue
(original residue number in PDB)		R409 R418 R443 N504 F564 R565 L566 K567 K568
Binding residue
(residue number reindexed from 1)		R89 R98 R123 N184 F244 R245 L246 K247 K248
Enzymatic activity
Catalytic site (original residue number in PDB) H363 D419 E522 G523 D524 S525 G526
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ch2, PDBe:4ch2, PDBj:4ch2
PDBsum4ch2
PubMed24316004
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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