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Structure of PDB 3fyi Chain B Binding Site BS01

Receptor Information >3fyi Chain B (length=256) Species: 1063 (Cereibacter sphaeroides) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] LEIIGRPQPGGTGFQPSASPVATQIHWLDGFILVIIAAITIFVTLLILYA VWRFHEKRNKVPARFTHNSPLEIAWTIVPIVILVAIGAFSLPVLFNQQEI PEADVTVKVTGYQWYWGYEYPDEEISFESYMIGSPATGGDNRMSPEVEQQ LIEAGYSRDEFLLATDTAMVVPVNKTVVVQVTGADVIHSWTVPAFGVKQD AVPGRLAQLWFRAEREGIFFGQCSELCGISHAYMPITVKVVSEEAYAAWL EQHHHH

Ligand information Ligand ID CU1 InChI InChI=1S/Cu/q+1 InChIKey VMQMZMRVKUZKQL-UHFFFAOYSA-N SMILES Software SMILES ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0 [Cu+] Formula Cu Name COPPER (I) ION ChEMBL DrugBank ZINC PDB chain 3fyi Chain B Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 3fyi Redox dependent conformational changes in cytochrome c oxidase suggest a gating mechanism for proton uptake. Resolution 2.2 Å Binding residue (original residue number in PDB) C252 E254 C256 H260 Binding residue (residue number reindexed from 1) C223 E225 C227 H231 Annotation score 1

Enzymatic activity Enzyme Commision number 7.1.1.9: cytochrome-c oxidase.

Gene Ontology Molecular Function GO:0004129 cytochrome-c oxidase activity GO:0005507 copper ion binding GO:0005515 protein binding GO:0016491 oxidoreductase activity GO:0046872 metal ion binding

	Biological Process
GO:0022900	electron transport chain
GO:0042773	ATP synthesis coupled electron transport
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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