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Structure of PDB 2vv4 Chain B Binding Site BS01

Receptor Information >2vv4 Chain B (length=247) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] PESADLRALAKHLYDSYIKSFPLTKAKARAILTGTTDKSPFVIYDMQSLM MGEDKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKY GVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEF AVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTPLLQEIYK

Ligand information Ligand ID 6OB InChI InChI=1S/C18H30O4/c1-2-3-4-5-6-7-11-16(19)13-10-14-17(20)12-8-9-15-18(21)22/h6-7,10,13,16,19H,2-5,8-9,11-12,14-15H2,1H3,(H,21,22)/b7-6-,13-10+/t16-/m0/s1 InChIKey OJFOOCZBVPQYRS-PSDPTOBYSA-N SMILES Software SMILES OpenEye OEToolkits 1.5.0 CCCCC\C=C/C[C@@H](\C=C\CC(=O)CCCCC(=O)O)O ACDLabs 10.04 O=C(O)CCCCC(=O)C/C=C/C(O)C\C=C/CCCCC CACTVS 3.341 CCCCCC=CC[CH](O)C=CCC(=O)CCCCC(O)=O CACTVS 3.341 CCCCC\C=C/C[C@H](O)\C=C\CC(=O)CCCCC(O)=O OpenEye OEToolkits 1.5.0 CCCCCC=CCC(C=CCC(=O)CCCCC(=O)O)O Formula C18 H30 O4 Name (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid ChEMBL DrugBank DB07208 ZINC ZINC000053682984 PDB chain 2vv4 Chain B Residue 1475 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2vv4 Structural Basis for the Activation of Pparg by Oxidised Fatty Acids Resolution 2.35 Å Binding residue (original residue number in PDB) C285 R288 S289 I326 L330 Binding residue (residue number reindexed from 1) C65 R68 S69 I106 L110 Annotation score 1

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0004879 nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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