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BioLiP

Structure of PDB 2rc7 Chain B Binding Site BS01

Receptor Information
>2rc7 Chain B (length=284) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSL
HSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNG
HWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRG
TELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPA
TPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYG
IGLPPNSPLTSNISELISQYKSHGFMDVLHDKWY
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain2rc7 Chain B Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2rc7 Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.
Resolution1.58 Å
Binding residue
(original residue number in PDB)		Y97 F124 S125 R130 S179 S180 D224
Binding residue
(residue number reindexed from 1)		Y94 F121 S122 R127 S176 S177 D221
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2rc7, PDBe:2rc7, PDBj:2rc7
PDBsum2rc7
PubMed18636091
UniProtQ9R1M7|NMD3A_RAT Glutamate receptor ionotropic, NMDA 3A (Gene Name=Grin3a)

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