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Structure of PDB 2eh6 Chain B Binding Site BS01

Receptor Information >2eh6 Chain B (length=375) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] TYLMNNYARLPVKFVRGKGVYLYDEEGKEYLDFVSGIGVNSLGHAYPKLT EALKEQVEKLLHVSNLYENPWQEELAHKLVKHFWTEGKVFFANSGTESVE AAIKLARKYWRDKGKNKWKFISFENSFHGRTYGSLSATGQPKFHKGFEPL VPGFSYAKLNDIDSVYKLLDEETAGIIIEVIQGEGGVNEASEDFLSKLQE ICKEKDVLLIIDEVQTGIGRTGEFYAYQHFNLKPDVIALAKGLGGGVPIG AILAREEVAQSFTPGSHGSTFGGNPLACRAGTVVVDEVEKLLPHVREVGN YFKEKLKELGKGKVKGRGLMLGLELERECKDYVLKALEKGLLINCTAGKV LRFLPPLIIQKEHIDRAISVLREIL

Ligand information Ligand ID PLP InChI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) InChIKey NGVDGCNFYWLIFO-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O OpenEye OEToolkits 1.5.0 Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O ACDLabs 10.04 O=P(O)(O)OCc1cnc(c(O)c1C=O)C Formula C8 H10 N O6 P Name PYRIDOXAL-5'-PHOSPHATE; VITAMIN B6 Phosphate ChEMBL CHEMBL82202 DrugBank DB00114 ZINC ZINC000001532514 PDB chain 2eh6 Chain B Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2eh6 Crystal structure of acetylornithine aminotransferase from Aquifex aeolicus VF5 Resolution 1.9 Å Binding residue (original residue number in PDB) G95 T96 F127 H128 E179 D212 V214 K241 Binding residue (residue number reindexed from 1) G95 T96 F127 H128 E179 D212 V214 K241 Annotation score 1

Enzymatic activity Catalytic site (original residue number in PDB) F127 E179 D212 Q215 K241 T270 R352 Catalytic site (residue number reindexed from 1) F127 E179 D212 Q215 K241 T270 R352 Enzyme Commision number 2.6.1.11: acetylornithine transaminase.

Gene Ontology Molecular Function GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity GO:0008483 transaminase activity GO:0030170 pyridoxal phosphate binding GO:0042802 identical protein binding

	Biological Process
GO:0006525	arginine metabolic process
GO:0006526	L-arginine biosynthetic process

	Cellular Component
GO:0005737	cytoplasm

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