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BioLiP

Structure of PDB 1fw6 Chain B Binding Site BS01

Receptor Information
>1fw6 Chain B (length=749) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERL
ARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEP
VRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKG
TVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPF
EPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATL
RALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLD
RVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQ
ILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPD
LDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYY
ERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVR
ERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGR
HPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGS
FVPAEEAHLPLFDGIYTRIGAGKSTFMVEMEEVALILKEATENSLVLLDE
VGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHV
AAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1fw6 Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		K1439 T1453 P1455 D1472
Binding residue
(residue number reindexed from 1)		K432 T446 P448 D465
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006281 DNA repair
GO:0006298 mismatch repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1fw6, PDBe:1fw6, PDBj:1fw6
PDBsum1fw6
PubMed11172706
UniProtQ56215|MUTS_THEAQ DNA mismatch repair protein MutS (Gene Name=mutS)

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