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BioLiP

Structure of PDB 1cr5 Chain B Binding Site BS01

Receptor Information
>1cr5 Chain B (length=176) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTRTRHLKVSNCPNNSYALANVAAVSPNDFPNNIYIIIDNLFVFTTRHSN
DIPPGTIGFNGNQRTWGGWSLNQDVQAKAFDLFKYSGKQSYLGSIDIDIS
FRADQDELAKQFVRCYESQIFSPTQYLIMEFQGHFFDLKIRNVQAIDLGD
IEPTSAVATGIETKGILTKQTQINFF
Ligand information
Ligand IDNEN
InChIInChI=1S/C6H9NO2/c1-2-7-5(8)3-4-6(7)9/h2-4H2,1H3
InChIKeyGHAZCVNUKKZTLG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CCN1C(=O)CCC1=O
ACDLabs 10.04O=C1N(C(=O)CC1)CC
FormulaC6 H9 N O2
Name1-ETHYL-PYRROLIDINE-2,5-DIONE
ChEMBL
DrugBankDB01902
ZINCZINC000001670837
PDB chain1cr5 Chain B Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1cr5 Crystal structure of the Sec18p N-terminal domain.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		C34 P35 N36 Y39 S71
Binding residue
(residue number reindexed from 1)		C12 P13 N14 Y17 S49
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0035494 SNARE complex disassembly

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Molecular Function
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Biological Process
External links
PDB RCSB:1cr5, PDBe:1cr5, PDBj:1cr5
PDBsum1cr5
PubMed10611286
UniProtP18759|SEC18_YEAST Vesicular-fusion protein SEC18 (Gene Name=SEC18)

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