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Structure of PDB 8wkp Chain AS8E Binding Site BS01

Receptor Information >8wkp Chain AS8E (length=126) Species: 330779 (Sulfolobus acidocaldarius DSM 639) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] SYYQGNDSRKITGGQKGKNRDKRKYELGSPPTETKISDKDIKEKDRVAGG NFKLRLRYASYANVYDPQSKTAKKVKIISVLESPANREYARRGIIVKGTL IQTELGKAKVTSRPGQDGIINALLLR

Ligand information >8wkp Chain A16S (length=1325) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] auuccgguugauccugccggacccgaccgcuaucgggguagggauaagcc augggagucuuacacucccggguaagggaguguggcggacggcugaguaa cacguggcuaaccuacccucgggacggggauaaccccgggaaacugggga uaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcu auaggcuauuucccguuuguagcgcccgaggauggggcuacggcccauca ggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccgu ggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacg gggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcu accccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcggggg aauaagcggggggcaagucuggugucagccgccgcgguaauaccagcucc gcgaguggucggggugauuacugggccuaaagcgccuguagccggcccac caagucgccccuuaaaguccccggcucaaccggggaacugggggcgauac uggugggcuagggggcgggagaggcgggggguacucccggaguaggggcg aaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuaga acgcgcccgacggugagaggcgaaagccgggggucccggcuguaaacgau gcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaag ccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaag gaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggag ucaacgccuggaaucuuaccggggagaccgcaguaugacggccaggcuaa cgaccuugccugacucgcggagaggaggugcauggccgucgccagcucgu guugugaaauguccgguuaaguccggcaacgagcgagacccccaccccua guugguauucuggacuccgguccagaaccacacuagggggacugccggcg uaagccggaggaaggagggggccacggcaggucagcaugccccgaaaccg ggccgcacgcggguuacaauggcagggacaacgggaugcuaccucgaaag ggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacc cgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcgg ugaauacgucccugcuccuugcaca ...<<<<<.[.((((>>>>>.<<<<<<<<......<<<.<<......<<< .<<<...<...<<<<<<<<......>>>>>>>>.>......<<<...... ..<<<<<<<..<<...<<<<<<<.<<<<.....<<<<........>>>>. .....>>>>...<<<<<<.<<.<<......>>>>.>>>>>>........< <<................>>>...>>>>>>>..>>>>>>>>>.<<<.... <<....<<<<<<<.......>>>>>>>..>>......>>>..<<<<<<<< ....>>>>...>>>>.>>><<<<<............>>>>>.<<<<.... >>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>> ..>>>....<<<<<.....>>>>>...<<<<<<<.........>>>>>>> .....<<<<<((......<<<<.....<<..))>>.......>>>>.>>> >>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<< <.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..> >>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<<....<<.... ....>>.......>>>>>>>.>>>.......<<....>>.>>>>>>>... .>>>.>>>...>>>...>>>>...<<<<<<.....>>>>>>......... <<<<<<..<<<.<<<<<<.<<<.....>>>.>>>>>>.>>>...<<..)) >>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)) )).].<.....<<<<<...<<.<<<<<..<<.<<<<<<<.......<<.. ......>>..........<<<...................<<.<<<.... ...>>>.>>..............<<.<<....<<<<<.......<<<<<< ............<<<<......>>>>..>>>>>>....<<<...<<<<<< <..........<<<<....>>>>.........>>>>>>>.....<<<<<. ...>>>>>.........>>>.........>>>...>>..>>>>.....>> >....>.>>>>>>>>.....<<<.<<<.......<..<...<<<<....> >>>...>....>......>>>.>>>...........<<<<<<<....... .>>>>>>>...........>>>>>....<<<<<<<<.......>>>>>>> >......>>....>>>>>...>...

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8wkp Structural basis of translation inhibition by a valine tRNA-derived fragment Resolution 4.62 Å Binding residue (original residue number in PDB) Q5 G6 N7 D8 R10 K11 K17 G18 R21 R24 K25 Y26 G29 S30 P31 P32 K43 K45 R47 G50 G51 N52 K54 L55 R56 Y62 N64 Y66 K71 T72 A73 K74 K75 P85 A86 N87 R88 V97 K98 T112 S113 R114 Q117 I120 N122 L124 Binding residue (residue number reindexed from 1) Q4 G5 N6 D7 R9 K10 K16 G17 R20 R23 K24 Y25 G28 S29 P30 P31 K42 K44 R46 G49 G50 N51 K53 L54 R55 Y61 N63 Y65 K70 T71 A72 K73 K74 P84 A85 N86 R87 V96 K97 T111 S112 R113 Q116 I119 N121 L123

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003735 structural constituent of ribosome

	Biological Process
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:1990904	ribonucleoprotein complex

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View graph for Cellular Component