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BioLiP

Structure of PDB 8z8j Chain A Binding Site BS01

Receptor Information
>8z8j Chain A (length=621) Species: 126796 (Thogoto virus (isolate SiAr 126)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDRPDHIDSRVWELSETQEDWITQVHGHVRRVVECWKYTICCLISNMHTH
RGAPQYDVFKWQDRSTIEWICSKKKVQYPERDTPDLYDNERAVAYKVLLV
SDLSDHSPTSGIYHDLAFNLEGEAEESCALVLRGSQLQDIKGFLCRALEW
VVSNNLTQEVVETISGEAKLQFSVGTTFRTLLKRDTDWDVIPTPRVEPNV
PRIEGRRWTQMKKLPLLKEKEGPPSPWRALLLGADSEYIVCPPGTDQEAI
SWIHSQSEIECIRESKSTPASVITCLTSSLQSFAEGNPVRSRIHEDIIAF
GINKKQEKKQSASSSASGEWKRAEYQVEEMSLPPWVEEEMVLLRSDQEDN
WIELEKNAIYTEVDGVAEGLVDKYIEIVGRTKVASVIEKWQIAATRTFSQ
LHTDRSRITACPIITRDPSGNCQFWGMVLLGPHHVKRDTDNAPLLIAEIM
GEDTEEKYPKHSVFSLKVEEKQFLLSLKITSFSRNKLYTFSNIRRVLIQP
ASIYSQVVLSRAAENNSLNLEVNPEIQLYLEGAQRGMTLYQWVRMILCLE
FLMAIYNNPQMEGFLANMRRLHMSRHAMMERRQVFLPFGSRPEDKVNECI
INNPIVAYLAKGWNSMPNVYY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8z8j Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses
Resolution3.16 Å
Binding residue
(original residue number in PDB)		R229 S268 G302 I303 N304 K305 K306 K309 Y326 H435 D441 N442 K461 K479 I480 S482
Binding residue
(residue number reindexed from 1)		R228 S267 G301 I302 N303 K304 K305 K308 Y325 H434 D440 N441 K460 K478 I479 S481
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Cellular Component
GO:0042025 host cell nucleus
GO:0044423 virion component

View graph for
Cellular Component
External links
PDB RCSB:8z8j, PDBe:8z8j, PDBj:8z8j
PDBsum8z8j
PubMed38816392
UniProtP27194|PA_THOGV Polymerase acidic protein (Gene Name=Segment)

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