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Structure of PDB 8w6r Chain A Binding Site BS01

Receptor Information >8w6r Chain A (length=411) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] VGQFWHVTDLHLDPTYHITDDRTKVCASSKGANASNPGPFGDVLCDSPYQ LILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTV QNLFPNLQVFPALGNHDYWPQDQLPIVTSKVYSAVADLWKPWLGEEAIST LKKGGFYSQKVASNPGLRIISLNTNLYYGPNIMTLNKTDPANQFEWLENT LNSSLWNKEKVYIIAHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVI AGQFYGHTHRDSLMVLSDKNGNPLNSVFVAPAVTPVKGVLQKETNNPGVR LFQYKPGDYTLLDMVQYYLNLTEANLKGESNWTLEYVLTQAYSVADLQPK SLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQHCKTLQVCAIMNLD SMSYDDCLKQH

Ligand information Ligand ID ZN InChI InChI=1S/Zn/q+2 InChIKey PTFCDOFLOPIGGS-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 [Zn++] ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Zn+2] Formula Zn Name ZINC ION ChEMBL CHEMBL1236970 DrugBank DB14532 ZINC PDB chain 8w6r Chain A Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8w6r SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Resolution 1.95 Å Binding residue (original residue number in PDB) D107 N148 H249 H290 Binding residue (residue number reindexed from 1) D74 N115 H216 H257 Annotation score 1

Enzymatic activity Enzyme Commision number 3.1.4.- 3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology Molecular Function GO:0004767 sphingomyelin phosphodiesterase activity GO:0008081 phosphoric diester hydrolase activity GO:0008270 zinc ion binding GO:0016787 hydrolase activity GO:0016887 ATP hydrolysis activity GO:0046872 metal ion binding

	Biological Process
GO:0006685	sphingomyelin catabolic process
GO:0008150	biological_process
GO:0009143	nucleoside triphosphate catabolic process
GO:0160049	negative regulation of cGAS/STING signaling pathway

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space

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