BioLiP

Structure of PDB 8eib Chain A Binding Site BS01

Receptor Information

>8eib Chain A (length=496) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TKLLNDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDV
ETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITT
LHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGN
QESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIV
EAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQL
LGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDRE
DITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIK
ATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSQFVEGV
RMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVA
AGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF

Ligand information

>8eib Chain C (length=15) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ICFQAAWMCLADDWT

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8eib Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
Resolution	3.76 Å
Binding residue (original residue number in PDB)	R474 R515 R582 R612 T653 Y654
Binding residue (residue number reindexed from 1)	R316 R357 R418 R448 T489 Y490

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0045296	cadherin binding

	Biological Process
GO:0007155	cell adhesion

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Molecular Function

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Biological Process

PDB	RCSB:8eib, PDBe:8eib, PDBj:8eib
PDBsum	8eib
PubMed	37914719
UniProt	P35222\|CTNB1_HUMAN Catenin beta-1 (Gene Name=CTNNB1)