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Structure of PDB 8dw8 Chain A Binding Site BS01

Receptor Information

>8dw8 Chain A (length=252) Species: 11801 (Moloney murine leukemia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TWLSDFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEARLG
IKPHIQRLLDQGILVPCQSPWNTPLLPVKTNDYRPVQDLREVNKRVEDIH
PTVPNPYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQPLFAFEWRDPE
MGISGQLTWTRLPQGFKNSPTLFDEALHRDLADFRIQHPDLILLQYVDDL
LLAATSELDCQQGTRALLQTLGNLGYRASAKKAQICQKQVKYLGYLLKEG
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Ligand information

>8dw8 Chain B (length=7) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

attagtt

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8dw8 Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites.
Resolution	2.58 Å
Binding residue (original residue number in PDB)	Y64 L99 R116
Binding residue (residue number reindexed from 1)	Y41 L76 R90

Enzymatic activity

Enzyme Commision number

2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-

External links

PDB	RCSB:8dw8, PDBe:8dw8, PDBj:8dw8
PDBsum	8dw8
PubMed	36516684
UniProt	P03355\|POL_MLVMS Gag-Pol polyprotein (Gene Name=gag-pol)

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