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BioLiP

Structure of PDB 7f4e Chain A Binding Site BS01

Receptor Information
>7f4e Chain A (length=278) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLAR
LKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKD
VLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKS
KLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREPQ
QPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLI
VHQYSDEFAEQLVEELGWQEDFEKILTA
Ligand information
>7f4e Chain C (length=9) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
TARKSTGGK
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7f4e Global profiling of regulatory elements in the histone benzoylation pathway.
Resolution1.78 Å
Binding residue
(original residue number in PDB)		F67 I117 H135 V182 F184 G185 E186 L188 V228 Y229 P230 E236
Binding residue
(residue number reindexed from 1)		F60 I110 H128 V175 F177 G178 E179 L181 V213 Y214 P215 E221
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:7f4e, PDBe:7f4e, PDBj:7f4e
PDBsum7f4e
PubMed35296687
UniProtP53686|HST2_YEAST NAD-dependent protein deacetylase HST2 (Gene Name=HST2)

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