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Structure of PDB 5udk Chain A Binding Site BS01

Receptor Information >5udk Chain A (length=461) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] HQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNL LAYVKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYH MGRLAEAQTYLDKVENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNY ERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLR QAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYA AKFYRRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMIQIKEATK GQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHR KAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIK IEQASLTRDKSINSLKKLVLRKLRRKALDLESLSLLGFVYKLEGNMNEAE EYYERAERLAA

Ligand information >5udk Chain B (length=4) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] aaaa ....

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5udk Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Resolution 1.65 Å Binding residue (original residue number in PDB) R38 K151 G154 Y157 R187 G190 F191 A194 Y218 R255 Y256 K259 R262 L286 H289 Q290 L293 K336 F339 V341 D345 V372 D379 Binding residue (residue number reindexed from 1) R31 K144 G147 Y150 R180 G183 F184 A187 Y211 R248 Y249 K252 R255 L279 H282 Q283 L286 K329 F332 V334 D338 V365 D372

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003723 RNA binding GO:0005515 protein binding

	Biological Process
GO:0009615	response to virus
GO:0019060	intracellular transport of viral protein in host cell
GO:0032091	negative regulation of protein binding
GO:0045070	positive regulation of viral genome replication
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response
GO:0051097	negative regulation of helicase activity
GO:0051607	defense response to virus
GO:0051707	response to other organism
GO:0071357	cellular response to type I interferon
GO:0071360	cellular response to exogenous dsRNA
GO:0140374	antiviral innate immune response

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043657	host cell

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