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BioLiP

Structure of PDB 5t2s Chain A Binding Site BS01

Receptor Information
>5t2s Chain A (length=247) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMTPKELLEWQTNWKKIMKRDSRIYFDITDDVEMNTYNKSKMDKRRDLLK
RGFLTLGAQITQFFDTTVTIVITRRSVENIYLLKDTDILSRAKKNYMKVW
SYEKAARFLKNLDVDIGENIVCRVICTTGQIPIRDLSADISQVLKEKRSI
KKVWTFGRNPACDYHLGNISRLSNKHFQILLGEDGNLLLNDISTNGTWLN
GQKVEKNSNQLLSQGDEITVGVGVESDILSLVIFINDKFKQCLEQNK
Ligand information
>5t2s Chain B (length=9) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DGESTDEDD
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t2s AND' logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		R273 S285 R286 L287 S288 N289 T309 N310
Binding residue
(residue number reindexed from 1)		R158 S170 R171 L172 S173 N174 T194 N195
Enzymatic activity
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
External links
PDB RCSB:5t2s, PDBe:5t2s, PDBj:5t2s
PDBsum5t2s
PubMed27681475
UniProtP22216|RAD53_YEAST Serine/threonine-protein kinase RAD53 (Gene Name=RAD53);
P32325|DBF4_YEAST DDK kinase regulatory subunit DBF4 (Gene Name=DBF4)

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