BioLiP

Structure of PDB 5mma Chain A Binding Site BS01

Receptor Information

>5mma Chain A (length=367) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DAELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIV
LQAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKA
SGPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPT
KAPSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEF
STPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYS
PVLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTP
PASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHL
GNNRTVSIDNLKPTSHQ

Ligand information

>5mma Chain C (length=19) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

attgtcatggaatttcgca

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5mma Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.
Resolution	2.55 Å
Binding residue (original residue number in PDB)	I112 L113 R114 P115 E207 S209 T210 Q215 S216 G218 K219 R222 R229 S258 P259 L347 N348 R350 T351
Binding residue (residue number reindexed from 1)	I104 L105 R106 P107 E199 S201 T202 Q207 S208 G210 K211 R214 R221 S250 P251 L339 N340 R342 T343

Enzymatic activity

Enzyme Commision number

2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding

	Biological Process
GO:0015074	DNA integration

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Molecular Function

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Biological Process

PDB	RCSB:5mma, PDBe:5mma, PDBj:5mma
PDBsum	5mma
PubMed	28737946
UniProt	P14350\|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)